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Uses of Isotope Effects in the Study of Enzymes

✍ Scribed by Dexter B. Northrop

Book ID
115639282
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
96 KB
Volume
24
Category
Article
ISSN
1046-2023

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## Abstract The basic principles and illustrative applications to enzyme mechanisms of solvent isotope effects, with emphasis on the use of rate measurements in mixtures of protium and deuterium oxides (β€˜proton inventories’), are reviewed over a period slightly shorter than the history of this Jour

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## Abstract Isotope effects are a powerful tool for determining the mechanisms of enzymatic reactions. Methods for measurement of isotope effects are reviewed and the equations that describe observed isotope effects and permit determination of intrinsic isotope effects on the isotope‐sensitive step