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The use of solvent isotope effects in the pursuit of enzyme mechanisms

✍ Scribed by Richard L. Schowen

Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
339 KB
Volume
50
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The basic principles and illustrative applications to enzyme mechanisms of solvent isotope effects, with emphasis on the use of rate measurements in mixtures of protium and deuterium oxides (β€˜proton inventories’), are reviewed over a period slightly shorter than the history of this Journal. The principles in their current formulation are traced to publications of the 1960s and the illustrations are taken from publications that have appeared in 2006–2007. Copyright Β© 2007 John Wiley & Sons, Ltd.

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