✦ LIBER ✦

The use of high-performance liquid chromatography in the quality control of oxytocin, vasopressin and synthetic analogues

✍ Scribed by F. Maxl; W. Siehr

Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 326 KB
Volume: 7
Category: Article
ISSN: 0731-7085
DOI: 10.1016/0731-7085(89)80085-8

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✦ Synopsis

Optimized C18 reversed-phase systems for oxytocin, desamino-oxytocin, lysine-vasopressin, ornithine-vasopressin and felypressin with gradient elution are discussed, focussing on precision, selectivity and ruggedness of the methods. Data from collaborative studies are presented, demonstrating the equivalence of high-performance liquid chromatography (HPLC) assays to bioassays. The findings suggest that HPLC is an excellent alternative to the time-consuming and less reliable animal testing.

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