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Behaviour of diastereoisomers of synthetic analogues of destruxin using high performance liquid chromatography and fast-atom bombardment mass spectrometry

✍ Scribed by M. Hubert; F. Cavelier; J. Verducci; J.-C. Cherton; A. Vey; C. Lange

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
116 KB
Volume
13
Category
Article
ISSN
0951-4198

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✦ Synopsis

The two synthetic diastereoisomers of propargyl-6-destruxin [Hpy-6-DTX] differing only in the configuration of the asymmetric carbon of the a-hydroxy acid are shown to be metabolized into the corresponding ring-opened peptides at quite different rates. The behaviours were followed using fast-Atom bombardment mass spectrometry in negative-ion mode and C4 large-pore reverse-phase high performance liquid chromatography and correlated with the very different biological activities.

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