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Evaluation of the use of microemulsions as eluents in high-performance liquid chromatography

✍ Scribed by Dina Tawfik Mohamed El-Sherbiny; Saadia Mohamed El-Ashry; Mohamed Ahmed Mustafa; Ali Abd-El-Rahman El-Emam; Steen Honoré Hansen

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
287 KB
Volume
26
Category
Article
ISSN
1615-9306

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✦ Synopsis

Abstract

An overview of the use of microemulsions as eluents in HPLC is given. The separation mechanisms involved are discussed and the technique is compared to solvent modified micellar chromatography as well as to ordinary reversed‐phase HPLC in order to evaluate differences and similarities. The microemulsion systems have been used for the separation of a number of antihypertensives and non steroidal antiinflammatory drug substances as well as for the analysis of bumetanide and acebutolol in plasma and urine. The plasma samples may be injected directly onto the HPLC system after a simple dilution.

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