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The unsolved enigma of CDH1 down-regulation in hereditary diffuse gastric cancer

✍ Scribed by Paola Concolino; Valerio Papa; Simona Mozzetti; Cristiano Ferlini; Fabio Pacelli; Enrica Martinelli; Riccardo Ricci; Flavia Filippetti; Giovanni Scambia; Giovanni Battista Doglietto


Book ID
116701382
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
309 KB
Volume
121
Category
Article
ISSN
0022-4804

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Novel germline CDH1 mutations in heredit
✍ Bostjan Humar; Tumi Toro; Francesco Graziano; Hansjakob MΓΌller; Zuzana Dobbie; H πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 414 KB

Hereditary diffuse gastric cancer (HDGC) is a recently defined cancer syndrome caused by inactivating, heterozygous germline mutations in the gene for the cell-to-cell adhesion protein E-cadherin (CDH1). Here, we describe the search for CDH1 mutations in 10 newly identified gastric cancer families.