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Cleft lip, cleft palate, hereditary diffuse gastric cancer and germline mutations in CDH1

✍ Scribed by Benusiglio, Patrick R.; Caron, Olivier; Consolino, Emilie; Duvillard, Pierre; Coulet, Florence; Blayau, Martine; Malka, David

Book ID
118054891
Publisher
John Wiley and Sons
Year
2012
Tongue
French
Weight
92 KB
Volume
132
Category
Article
ISSN
0020-7136

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Hereditary diffuse gastric cancer (HDGC) is a recently defined cancer syndrome caused by inactivating, heterozygous germline mutations in the gene for the cell-to-cell adhesion protein E-cadherin (CDH1). Here, we describe the search for CDH1 mutations in 10 newly identified gastric cancer families.