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CDH1 germline mutations and the hereditary diffuse gastric and lobular breast cancer syndrome: a multicentre study

✍ Scribed by Benusiglio, Patrick R. (author);Malka, David (author);Rouleau, Etienne (author);Pauw, Antoine De (author);Buecher, Bruno (author);Noguès, Catherine (author);Fourme, Emmanuelle (author);Colas, Chrystelle (author);Coulet, Florence (author);Warcoin, Mathilde (author);Grandjouan, Sophie (author);Sezeur, Alain (author);Laurent-Puig, Pierre (author);Molière, Diane (author);Tlemsani, Camille (author);Maria, Marina Di (author);Byrde, Veronique (author);Delaloge, Suzette (author);Blayau, Martine (author);Caron, Olivier (author)

Book ID
121873995
Publisher
BMJ Publishing Group
Year
2013
Tongue
English
Weight
96 KB
Volume
50
Category
Article
ISSN
0022-2593

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Novel germline CDH1 mutations in heredit
Novel germline CDH1 mutations in hereditary diffuse gastric cancer families
✍ Bostjan Humar; Tumi Toro; Francesco Graziano; Hansjakob Müller; Zuzana Dobbie; H 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 414 KB

Hereditary diffuse gastric cancer (HDGC) is a recently defined cancer syndrome caused by inactivating, heterozygous germline mutations in the gene for the cell-to-cell adhesion protein E-cadherin (CDH1). Here, we describe the search for CDH1 mutations in 10 newly identified gastric cancer families.