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The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg

✍ Scribed by Aaron Ciechanover; Patrik Brundin

Book ID
117608775
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
333 KB
Volume
40
Category
Article
ISSN
0896-6273

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## Abstract The ubiquitin proteasome system is a potent regulatory mechanism used to control protein stability in numerous cellular processes, including neural development. Many neurodegenerative diseases are featured by the accumulation of UPS‐associated proteins, suggesting the UPS dysfunction ma