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The ubiquitin–proteasome pathway in Parkinson's disease and other neurodegenerative diseases

✍ Scribed by Christopher A. Ross; Cecile M. Pickart

Book ID
113925384
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
613 KB
Volume
14
Category
Article
ISSN
0962-8924

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## Abstract Increasing genetic, pathological, and experimental evidence suggest that neurodegeneration in both familial and sporadic forms of Parkinson's disease (PD) may be related to a defect in the capacity of the ubiquitin–proteasome system (UPS) to clear unwanted proteins, resulting in protein