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The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases

✍ Scribed by Mei Ding; Kang Shen

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
102 KB
Volume
30
Category
Article
ISSN
0265-9247

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✦ Synopsis

Abstract

The ubiquitin proteasome system is a potent regulatory mechanism used to control protein stability in numerous cellular processes, including neural development. Many neurodegenerative diseases are featured by the accumulation of UPS‐associated proteins, suggesting the UPS dysfunction may be crucial for pathogenesis. Recent experiments have highlighted the UPS as a key player during synaptic development. Here we summarize recent discoveries centered on the role of the UPS in synapse remodeling and draw attention to the potential link between the synaptic UPS dysfunction and the pathology of neurodegenerative diseases. BioEssays 30:1075–1083, 2008. © 2008 Wiley Periodicals, Inc.

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