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The ubiquitin proteasome system and its involvement in cell death pathways

✍ Scribed by Bernassola, F; Ciechanover, A; Melino, G

Book ID: 109841243
Publisher: Nature Publishing Group
Year: 2009
Tongue: English
Weight: 140 KB
Volume: 17
Category: Article
ISSN: 1350-9047
DOI: 10.1038/cdd.2009.189

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## Abstract Huntington's disease (HD) is a progressive, autosomal dominant neurodegenerative disease caused by an abnormally expanded CAG repeat in the HD gene. Ubiquitylated aggregates containing mutant huntingtin protein in neurons are hallmarks of HD. Misfolded mutant huntingtin monomers, oligom