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The uraemic milieu, the ubiquitin–proteasome pathway and the endothelial cell: a pathway to dysfunction

✍ Scribed by Robert G. Fassett

Book ID
110111387
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
50 KB
Volume
96
Category
Article
ISSN
0958-0670

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## Abstract **Background:** Recent work has demonstrated the role of cdc kinase subunit 1 (Cks1) in the ubiquitin‐proteasome dependent degradation of CDK inhibitor p27^__Kip1__^ protein as an essential cofactor for SCF^Skp2^ ubiquitin ligase. Although over‐expression of Cks1 protein as well as it o