Seek and destroy: The ubiquitin-proteasome system in cardiac disease
✍ Scribed by Jessica E. Rodríoguez; Jonathan C. Schisler; Cam Patterson; Monte S. Willis
- Book ID
- 107541706
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 424 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1522-6417
No coin nor oath required. For personal study only.
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## Abstract The ubiquitin–proteasome system (UPS) is the major proteolytic pathway that degrades intracellular proteins in a regulated manner. Deregulation of the UPS has been implicated in the pathogenesis of many neurodegenerative disorders like Alzheimer's disease, Parkinson's diseases, Huntingt
## Abstract The ubiquitin proteasome system is a potent regulatory mechanism used to control protein stability in numerous cellular processes, including neural development. Many neurodegenerative diseases are featured by the accumulation of UPS‐associated proteins, suggesting the UPS dysfunction ma