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The Total synthesis of (+)-artemisinin and (+)-9-desmethyltemesinin

โœ Scribed by Mitchell A. Avery; Clive Jennings-White; Wesley K.M. Chong


Book ID
108383072
Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
217 KB
Volume
28
Category
Article
ISSN
0040-4039

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The total synthesis of the novel antimalarial drug, a sesquiterpene endoperoxide, (+)-artemisinin is described. The approach is flexible and stereoselective. The use of an intermolecular radical reaction on an intermediate iodolactone and a Wittig reaction on a ketone were employed for the synthesis

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