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Stereoselective Total Synthesis of (+)-Artemisinin.

โœ Scribed by J. S. Yadav; R. Satheesh Babu; G. Sabitha


Publisher
John Wiley and Sons
Year
2003
Weight
58 KB
Volume
34
Category
Article
ISSN
0931-7597

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The total synthesis of the novel antimalarial drug, a sesquiterpene endoperoxide, (+)-artemisinin is described. The approach is flexible and stereoselective. The use of an intermolecular radical reaction on an intermediate iodolactone and a Wittig reaction on a ketone were employed for the synthesis

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