The total synthesis of the novel antimalarial drug, a sesquiterpene endoperoxide, (+)-artemisinin is described. The approach is flexible and stereoselective. The use of an intermolecular radical reaction on an intermediate iodolactone and a Wittig reaction on a ketone were employed for the synthesis
Stereoselective Total Synthesis of (+)-Artemisinin.
โ Scribed by J. S. Yadav; R. Satheesh Babu; G. Sabitha
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 58 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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๐ SIMILAR VOLUMES
A stereoselective synthesis, of artemisinin 11 base8 on intramolecular Diels-Alder reaction of the triene 4 derived from (+)isolimonene 2 is described. Recently there has been a considerable interest in the chemistry 1 and total synthesis 2 of artemisinin, a promising antimalarial compound of Chine
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