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The synthesis of γ-substituted glutamic acids via a glutamic acid γ-enolate synthon

✍ Scribed by Andrew N.C. Johnstone; Stefania Lopatriello; Michael North


Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
234 KB
Volume
35
Category
Article
ISSN
0040-4039

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The Strecker reaction of the product from the treatment of the sodium salt of 7-keto acids with (S)-phenylglycinol followed by heating the products to 200 °C gives the bicyclic lactones 9 and 10. Alkylation of 9 provides 11 and 12. Both 9b and lla are converted into the corresponding substituted gl