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Enantioselective syntheses of α-substituted glutamic acids and α,γ-disubstituted glutamic acids by an asymmetric Strecker reaction

✍ Scribed by Dawei Ma; Guozhi Tang; Hongqi Tian; Guixiang Zou

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
199 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

The Strecker reaction of the product from the treatment of the sodium salt of 7-keto acids with (S)-phenylglycinol followed by heating the products to 200 °C gives the bicyclic lactones 9 and 10.

Alkylation of 9 provides 11 and 12. Both 9b and lla are converted into the corresponding substituted glutamic acids via reductive cleavage and hydrolysis.

📜 SIMILAR VOLUMES

ChemInform Abstract: Asymmetric Synthesi
ChemInform Abstract: Asymmetric Synthesis of α,α-Disubstituted Amino Acids by Diastereoselective Functionalization of Enantiopure Phenyloxazinones, Derivatives of Asymmetric Strecker Reaction Products of Aldehydes.
✍ Ke Ding; Dawei Ma 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 39 KB 👁 1 views

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