## Abstract The synthesis of the trichloromethyl analogue of benzyloxycarbonylβthreonine is described. This precursor was reduced by tritium gas to give [methylβ^3^H~3~]βthreonine and its allo isomer. They were separated by HPLC using a chiral stationnary phase. They have a molar specific activity
The synthesis of tritiated methoxamine with high specific activity
β Scribed by R. M. Demarinis; A. J. Villani; D. Brungard; J. Meier
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- French
- Weight
- 153 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0022-2135
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β¦ Synopsis
Abstract
Tritiated methoxamine with a specific activity of 28.5 Ci/mmol was prepared by iodination of methoxamine followed by catalytic tritiation.
π SIMILAR VOLUMES
Due to the desire for biological assay techniques of greater sensitivity and specificity than presently exist for the antihypertensive drug guanethidine, tritium labeled guanethidine of high specific activity was prepared for use in radioimmunoassay procedures. This drug has been labeled in other po
Thiomethylenes-3 H] CEP-1347 (5) was synthesized by the tritiation of diformyl precursor 3 with NaB 3 H 4 followed by treatment with ethanethiol. [Methyl ester-3 H] CEP-1347 ( 7) was prepared at even higher specific activity by the alkylation of precursor 6 with C 3 H 3 I.