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Synthesis of tritiated threonine with a high specific activity

✍ Scribed by Jean-Michel Delacotte; Hervé Galons; Dominique Schott; Jean-Louis Morgat

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
294 KB
Volume
29
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of the trichloromethyl analogue of benzyloxycarbonyl‐threonine is described. This precursor was reduced by tritium gas to give [methyl‐^3^H~3~]‐threonine and its allo isomer. They were separated by HPLC using a chiral stationnary phase. They have a molar specific activity of 3190 GBq/mmol, 86 Ci/mmol.

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