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Tritiation of CEP-1347 at high specific activity using several methods

✍ Scribed by Judith A. Egan; Crist N. Filer; Scot Pounds; Thomas Connors; Ernest Knight Jr; Robert L. Hudkins

Publisher: John Wiley and Sons
Year: 2005
Tongue: French
Weight: 88 KB
Volume: 48
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.927

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✦ Synopsis

Thiomethylenes-3 H] CEP-1347 (5) was synthesized by the tritiation of diformyl precursor 3 with NaB 3 H 4 followed by treatment with ethanethiol. [Methyl ester-3 H] CEP-1347 ( 7) was prepared at even higher specific activity by the alkylation of precursor 6 with C 3 H 3 I.

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