The synthesis of the potent anti-herpes virus agent, E-5(2-bromovinyl)-2′-deoxyuridine and related compounds
✍ Scribed by A.S. Jones; G. Verhelst; R.T. Walker
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- French
- Weight
- 225 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Elemental
analyses gave satisfactory values.
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## Abstract With development of antiviral drugs, the need to identify a virus as to drug sensitivity becomes increasingly of importance. The compound (E)‐5‐(2‐bromovinyl)‐2′‐deoxyuridine (BVDU) has been shown to be much more inhibitory to the replication of herpes simplex virus type 1 (HSV‐1) and v
The influence of (E)-5-(2-bromovinyl)-2'-de~xyuridine (BVDU), caffeic acid oxidation product (KOP), and trisodiumphosphonoformate (TPF) on the course of the primary cutaneous herpes simplex virus infection was investigated by means of a guinea pig test model. The antiviral substances were applied in