Therapeutic effect of (E)-5-(2-bromovinyl)-2′-deoxyuridine, caffeic acid oxidation product, and trisodiumphosphonoformate on cutaneous herpes simplex virus type 1 infection in guinea pigs
✍ Scribed by Dr. Bjorn Helbig; Andreas Sauerbrei; Renate Klöcking; Peter Wutzler; Norbert Wicht; Uwe Wiedemann; Gottfried Herrmann
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 383 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0146-6615
No coin nor oath required. For personal study only.
✦ Synopsis
The influence of (E)-5-(2-bromovinyl)-2'-de~xyuridine (BVDU), caffeic acid oxidation product (KOP), and trisodiumphosphonoformate (TPF) on the course of the primary cutaneous herpes simplex virus infection was investigated by means of a guinea pig test model. The antiviral substances were applied in an ointment with 10% urea as a penetration mediator.
When the treatment was initiated 15 minutes after virus inoculation, 3% BVDU effectively inhibited the development of herpetic vesicles and 0.1 % BVDU prevented the appearance of herpetic satellites. Under the same conditions 1% and 3% KOP ointments inhibited the appearance of satellites; and 0.5% TPF ointment completely inhibited the development of cutaneous herpes lesions. Prophylactic drug administration given 24, 20, and 4 hours before virus inoculation was without any protective effect.