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The synthesis of some tritium-labelled terminators of DNA synthesis

✍ Scribed by Georgy V. Sidorov; Nykolai F. Myasoedov; Maxim V. Yasko

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
475 KB
Volume
34
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

2′,3′‐Dideoxythymidine, 2′,3′‐dideoxyadenosine, 2′,3′‐dideoxycytidine‐5′‐phosphonate, thymidine‐5′‐phosphonate, labelled with tritium in the carbohydrate residue; thymidine‐5′‐methylphosphonate labelled in the methyl of the phosphonate group and 2′,3′‐dideoxyadenosine labelled in the base and/or carbohydrate residue were prepared by hydrogenolysis with tritium gas. The reaction of solid state catalytic hydrogenation was studied and tritium‐labelled azydothymidine, azydothymidine‐5′‐phosphonate, acyclovire, acyclovire‐5′‐phosphonate were synthesized. A number of general approaches to the synthesis of tritium‐labelled terminators of DNA synthesis were formulated.

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