✍ Scribed by Wenis, E. ;Gardner, Thomas S.
No coin nor oath required. For personal study only.
Sir P. C. Ray Fellow's Laboratory, University b l l e g e of Science and Technology. Calcutta. t The authon are indebted to Dr. S. K.' Muker'ee Herbarium Curator, Royal. Botanic Garden. Sibpur. hicutts. for suggtwionn on botanlcnl matter.
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A major chromogen found in p-aminosalicylic acid and sodium p-aminosalicylate dosage forms was identified to be 3,3'-dihydroxyazoxybenzene. This compound could he produced by oxidation or sunlight irradiation of m-aminophenol, a common impurity of paminosalicylic acid and sodium p-aminosalicylate. M
These data indicated that quantitative conversion of procarbazine hydrochloride to the azo compound occurred during the titration. No evident substitution of iodine into the phenyl ring resulted, therefore eliminating aromatic substitution as a source of interference.
5-Aminosalicyl-L-aspartic acid (5-ASA-Asp) and 5-aminosalicyl-L-glutamic acid (5-ASA-Glu) were synthesized and their properties as colon-speci®c prodrugs of 5aminosalicylic acid (5-ASA) were investigated employing rats as test animals. Incubation of 5-ASA-Asp and 5-ASA-Glu with the homogenates of ti