Analytical applications of p-nitrosobenzoic acid I: Specific colorimetric determination of m-aminophenol in p-aminosalicylic acid and sodium p-aminosalicylate
β Scribed by I. K. Shih
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 492 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0022-3549
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β¦ Synopsis
These data indicated that quantitative conversion of procarbazine hydrochloride to the azo compound occurred during the titration. No evident substitution of iodine into the phenyl ring resulted, therefore eliminating aromatic substitution as a source of interference.
π SIMILAR VOLUMES
A major chromogen found in p-aminosalicylic acid and sodium p-aminosalicylate dosage forms was identified to be 3,3'-dihydroxyazoxybenzene. This compound could he produced by oxidation or sunlight irradiation of m-aminophenol, a common impurity of paminosalicylic acid and sodium p-aminosalicylate. M
## Abstract An ionβpair high performance liquid chromatographic method was developed for the simultaneous determination of __p__βaminosalicylic acid (PAS) and its degradation product __m__βaminophenol (MAP) in a newly developed multiparticular drug delivery system. Owing to the concencentration dif
A colorimetric method based on the interaction between the chloramphenicol degradation product 1-(4'-nitrophenyl)-2-aminopropane-1,3-diol and the 2,4,6-trinitrobenzenesulfonic acid reagent was developed. Analytical solutions were reacted with the reagent at pH 9.1 for 20 min at room temperature, and