Determination of sodium p-aminosalicylate in the presence of m-aminophenol
โ Scribed by Martin I. Blake; Kenneth Makris; James Hunt
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 263 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
These data indicated that quantitative conversion of procarbazine hydrochloride to the azo compound occurred during the titration. No evident substitution of iodine into the phenyl ring resulted, therefore eliminating aromatic substitution as a source of interference.
Isoniazid in the presence of excess of sodium p-aminosalicylate is estimated by differential titration of the acetonitrile extract of the mixture against perchloric acid. Sodium p-aminosalicylate content is then calculated from the total basicity obtained by direct titration of the mixture with the
A major chromogen found in p-aminosalicylic acid and sodium p-aminosalicylate dosage forms was identified to be 3,3'-dihydroxyazoxybenzene. This compound could he produced by oxidation or sunlight irradiation of m-aminophenol, a common impurity of paminosalicylic acid and sodium p-aminosalicylate. M