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Nonaqueous titrimetric determination of isoniazid in presence of excess of sodium p-aminosalicylate in dosage forms

โœ Scribed by C. J. Shishoo; M. B. Devani

Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
224 KB
Volume
59
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

Isoniazid in the presence of excess of sodium p-aminosalicylate is estimated by differential titration of the acetonitrile extract of the mixture against perchloric acid. Sodium p-aminosalicylate content is then calculated from the total basicity obtained by direct titration of the mixture with the same titrant. The procedure is applied to determine the isoniazid and sodium p-aminosalicylate content of tablets, granules, and cachets. The results obtained are comparable to those obtained by the official method.

Keyphrases 0 Isoniazid, Na p-aminosalicylate mixture-analysis 0 Differential titration, nonaqueous-analysis 0 Perchloric acid-

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