✦ LIBER ✦

Identity of a major chromogen in p-Aminosalicylic Acid and Sodium p-Aminosalicylate Dosage Forms

✍ Scribed by I. K. Shih

Publisher: John Wiley and Sons
Year: 1971
Tongue: English
Weight: 255 KB
Volume: 60
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600601229

No coin nor oath required. For personal study only.

✦ Synopsis

A major chromogen found in p-aminosalicylic acid and sodium p-aminosalicylate dosage forms was identified to be 3,3'-dihydroxyazoxybenzene. This compound could he produced by oxidation or sunlight irradiation of m-aminophenol, a common impurity of paminosalicylic acid and sodium p-aminosalicylate. Methods of synthesis for 3,3'-dihydroxyazoxybenzene are described.

Keyphrases 0 p-Aminosalicylic acid, sodium p-aminosalicylate dosage form-identification of major chromogen, 3,3 '-dihydroxyazoxybenzene 0 3,3 '-Dihydroxyazoxybenzene-identification as a major chromogen in p-aminosalicylic acid, sodium p-aminosalicylate dosage form, synthesis, photosynthesis 0 Sodium p-aminosalicylate, p-aminosalicylic acid dosage form-identification of major chromogen, 3,3'-dihydroxyazoxybenzene

📜 SIMILAR VOLUMES

Determination of m-aminophenol (MAP) in

Determination of m-aminophenol (MAP) in p-aminosalicylic acid (PAS) and sodium p-aminosalicylate (PASNa)

✍ R. B. Luers Jr.; L. B. Stadler 📂 Article 📅 1962 🏛 John Wiley and Sons 🌐 English ⚖ 248 KB 👁 1 views

Analytical applications of p-nitrosobenz

Analytical applications of p-nitrosobenzoic acid I: Specific colorimetric determination of m-aminophenol in p-aminosalicylic acid and sodium p-aminosalicylate

✍ I. K. Shih 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 English ⚖ 492 KB 👁 1 views

These data indicated that quantitative conversion of procarbazine hydrochloride to the azo compound occurred during the titration. No evident substitution of iodine into the phenyl ring resulted, therefore eliminating aromatic substitution as a source of interference.

Analysis of p-aminosalicylic acid, its s

Analysis of p-aminosalicylic acid, its salts and dosage forms, by nonaqueous titration

✍ James Hunt; Martin I. Blake 📂 Article 📅 1970 🏛 John Wiley and Sons 🌐 English ⚖ 347 KB 👁 1 views

Nonaqueous titrimetric determination of

Nonaqueous titrimetric determination of isoniazid in presence of excess of sodium p-aminosalicylate in dosage forms

✍ C. J. Shishoo; M. B. Devani 📂 Article 📅 1970 🏛 John Wiley and Sons 🌐 English ⚖ 224 KB 👁 1 views

Isoniazid in the presence of excess of sodium p-aminosalicylate is estimated by differential titration of the acetonitrile extract of the mixture against perchloric acid. Sodium p-aminosalicylate content is then calculated from the total basicity obtained by direct titration of the mixture with the