The metabolism of p‐aminosalicylic acid (PAS) in man
✍ Scribed by Way, E.Leong ;Peng, Chin‐Tzu ;Allawala, Naseem ;Daniels, T.C.
- Publisher
- Elsevier
- Year
- 1955
- Weight
- 482 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0095-9553
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📜 SIMILAR VOLUMES
Sir P. C. Ray Fellow's Laboratory, University b l l e g e of Science and Technology. Calcutta. t The authon are indebted to Dr. S. K.' Muker'ee Herbarium Curator, Royal. Botanic Garden. Sibpur. hicutts. for suggtwionn on botanlcnl matter.
The syntheses of five derivatives of PAS are described. T h e compounds were prepared for study as agents having possible increased antimetabolite and/of antimicrobial properties. T IS KNOWN that many azo compounds are useful
A major chromogen found in p-aminosalicylic acid and sodium p-aminosalicylate dosage forms was identified to be 3,3'-dihydroxyazoxybenzene. This compound could he produced by oxidation or sunlight irradiation of m-aminophenol, a common impurity of paminosalicylic acid and sodium p-aminosalicylate. M
These data indicated that quantitative conversion of procarbazine hydrochloride to the azo compound occurred during the titration. No evident substitution of iodine into the phenyl ring resulted, therefore eliminating aromatic substitution as a source of interference.