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The Synthesis of [methylenedioxy-14C]paroxetine BRL 29060A

✍ Scribed by K W M Lawrie; D C Rustidge

Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 229 KB
Volume: 33
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580330814

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✦ Synopsis

Abstract

Paroxetine (1), BRL 29060A, a potent antidepressant, has been prepared radiolabelled with carbon‐14 in the methylenedioxy group in 5 steps and 20.9% overall yield from [^14^C]dibromomethane. Two altenative preparations of 3,4‐[methylenedioxy‐^14^C]phenol (2) are also described.

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