## Abstract Paroxetine (1), BRL 29060A, a potent antidepressant, has been prepared radiolabelled with carbonβ14 in the methylenedioxy group in 5 steps and 20.9% overall yield from [^14^C]dibromomethane. Two altenative preparations of 3,4β[__methylenedioxy__β^14^C]phenol (2) are also described.
The synthesis of [3H] renzapride (BRL 24924)
β Scribed by R. Freer; S. Nash
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- French
- Weight
- 318 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract BRL 26850A has been extensively reported ^1^ as a novel Ξ²βadrenoceptor agonist. In order to perform metabolism studies, carbonβ14 radiolabelled BRL 26830A was synthesised from potassium [^14^C]cyanide. As BRL 26830A contains two asymmetric centres, the initial product required resolutio
A synthesis of thebaine is described where the C-1 position is labelled with tritium to specific activity of 16 Ci/mmole. From codeine (a, 1iodocodeine ( 1 ) was prepared and converted to 1-iodothebaine (T, in 3 steps. The subsequent key reaction was the selective hydrogenolysis of the carbon-iodine
## Abstract [Fluorophenylβ^3^H(N)] Ocfentanil (1b) and [fluorophenylβ^3^H(N)] brifentanil [2b] were synthesized by catalytic tritiation of appropriate bromo precursors (1a, 2a). The products were purifled by preparative HPLC and characterized chromatographically and by proton decoupled ^3^H NMR.
## Abstract For Abstract see ChemInform Abstract in Full Text.