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The synthesis of glutamic acid in the absence of enzymes: Implications for biogenesis

✍ Scribed by Harold Morowitz; Eta Peterson; Sherwood Chang


Publisher
Springer Netherlands
Year
1995
Tongue
English
Weight
297 KB
Volume
25
Category
Article
ISSN
1573-0875

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## Abstract A convenient two‐step chemical synthesis of DL‐[2‐^13^C]‐glutamic acid from methyl acrylate and diethyl acetamidomalonate is described. Synthesis of the Michael adduct (III) was effected in quantitative yield by employing strong amino bases as catalysts. The reactivities of three such c