A synthesis of the title compound from /13Clparaformaldehyde and [15N)ammonium chloride V f 8 ethyl 2-(1 ,3-/2-13Cldithianyl) acetate 3a is described. Ethyl/3-13C13-oxopropanoate derived in sl'tu from 3a was converted by a stepwise Strecker procedure to DL-[ 2-13C,15Nlaspartic acid 7a.
The Synthesis of DL-Aspartic Acid-4-C 14 1
โ Scribed by Wang, S. C.; Winnick, T.; Hummel, J. P.
- Book ID
- 127139530
- Publisher
- American Chemical Society
- Year
- 1951
- Tongue
- English
- Weight
- 148 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
D L -t y r o ~i n e -4 -~~C has been synthesized with an overall yield 29.3 based on phenol-1-14C as the starting material. Anisole-l-14C was prepared by methylation of phenol-1-14C with dimethyl sulfate. The radioactive anisole was then converted to p-anisaldehyde-4-14C by a modijied Gattermann rea
A new method of synthesis of DL-[ 7-14C]indospicine and DL-2-amino-[ 7-1 4C]pimelic acid and their nonradioactive equivalents is reported. The combined radiochemical yield of both compounds, starting from potassium 1 14C]cyanide was 15.3%. Indospicine was isolated as the flavianate.