DL-2-Phenylglycine-I-14C was prepared in good yield employing a modified Strecker synthesis. The resolution of DL-2-phenylglycine into its pure enantiomorphs was accomplished by the stereoselective enzymatic hydrolysis of the N-chloroacetyl derivative of the Loptical isomer using hog kidney acylase.
Synthesis of DL-[7-14C]indospicine and DL-2-amino[7-14C]pimelic acid
β Scribed by Elzbieta Wieczorkowska; Mervyn P. Hegarty
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- French
- Weight
- 322 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0022-2135
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β¦ Synopsis
A new method of synthesis of DL-[ 7-14C]indospicine and DL-2-amino-[ 7-1 4C]pimelic acid and their nonradioactive equivalents is reported. The combined radiochemical yield of both compounds, starting from potassium 1 14C]cyanide was 15.3%. Indospicine was isolated as the flavianate.
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