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The synthesis of disodium-3-amino-1-hydroxypropane-1, 1-diphosphonate-1-14C. (APD· 2Na)

✍ Scribed by Ernest Magnien; Mujahid Shaikh; John T. Suh; Howard Jones

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
169 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Disodium‐3‐amino‐1‐hydroxy‐1, 1‐diphosphonate‐1‐^14^C (APD 2Na), a powerful calcium binding agent and potential drug for the treatment of Paget's Disease was synthesized. The reaction was carried out by reacting β‐alanine (1‐^14^C) with phosphorus acid and phosphorus trichloride in chlorobenzene. Treatment of the resultant APD with two equivalents of sodium hydroxide gave the title compound.

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