Absolute configurations have been assigned to the enantiomers of the antimalarial drug quinacrine dihydrochloride. Condensation of ( -)-(R)-4-amino-l-diethylaminopentane (from L-glutamic acid) with 6,9-dichloro-2-methoxyacridine gave ( -)-(R)-6-chloro-9-(4'diethylamino-1'-methylbutyl) amino-2-methox
Synthesis of 6-chloro-9–[(4-(ethlethyl-1–14C-amino)-1-methylbutyl)amino]-2-methoxyacridine
✍ Scribed by H. Minato; Y. Katsuyama; T. Nagasaki
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- French
- Weight
- 220 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The carbon of the N‐ethyl group of the side‐chain of atabrine (I) has been labelled with carbon‐14 as part of a metabolic study of this compound. The overall radiochemical yield was 38% based on ethyl‐1–^14^C iodide.
📜 SIMILAR VOLUMES
## Abstract A convenient synthesis of the ^14^C‐labelled chloromethyl ketone analog of leucine is reported. Modification of previously published conditions allowed for the facile synthesis of: 2–^14^C‐3‐amino‐1‐chloro‐5‐methylhexan‐2‐one hydrochloride in four steps from 1‐^14^C‐DL‐leucine in 85.7%
A seven-step 'synthesis of 3-amino-l-methyl-9FJ-[4-l 'Clpyrido-[ 3,4-&] indole from DL-[methylene-"C] tryptophan and acetaldehyde is described.
1 -M e t h y l -4 -[ 4 -( 7 -c h l o r 0 -4 -q ~n i n o l y l -[ 3 -~~C 1amino)-benzoyllpiperazine (V) was prepared for pharmacokinetic and pharmacodynamic evaluation. The synthesis of V was accomplished first by a modified Claisen ester condensation reaction of diethyl-[2-14C]-malonate, triethyl or