## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of disodium (+)-(Z)-[[[1-(2-amino-4-[2-14c]thiazolyl)2-[[(2s,3s)-2-(carbamoyloxymethyl)-4-oxo-1-sulfonato-3-azetidinyl]amlno]-2-oxoethylidene]amino]oxy]acetate
โ Scribed by M. Imanishi; M. Tomimoto; M. Watanabe; N. Hayashi
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- French
- Weight
- 273 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0022-2135
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โฆ Synopsis
Disodium (+)-(Z)-[[[1-(2-amino-4-~2-14C]thiazolyl)-2-[[(2S,3S)-2-(carbamoyloxymethyl)-4-oxo-l-sulfonato-3-azet izinyl]amino-2-oxoethylidene]aminoloxylacetate ([14C]AMA-1080) was synthesized via [2-(2-chloroacetamido-4-[2-~~C]th~azolyl)-(Z)-2-(4-nitrobenzyloxycarbnylmethoxyimino)]acetic acid from [14C]thiourea. Trisodium (+)-(2)-[[[1-(2-amin0-4-[2-14C]thiazolyl)-2-[[( 1S,2S)-3-carbamoyloxy-1-carboxylato-2-sulfonatoaminopropyl]amino]-2-oxoethylidene]amino]oxy]acetate ([14C]AMA-1294) as t h e principal metabolite of [14C]AMA-1080 was also prepared.
๐ SIMILAR VOLUMES
The title compound, CGS 148248, was synthesized with a '%-label in the azepine ring in 14 steps starting with l-bromo-3-phenylpropane (1> and K1%N in an overall yield of 1.31%. The reaction of I with K 1 k N yielded the nitrile 2 which upon hydrolysis followed by ring closure gave a-tetral~ne-l-~~c
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.