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Synthesis of disodium (+)-(Z)-[[[1-(2-amino-4-[2-14c]thiazolyl)2-[[(2s,3s)-2-(carbamoyloxymethyl)-4-oxo-1-sulfonato-3-azetidinyl]amlno]-2-oxoethylidene]amino]oxy]acetate

โœ Scribed by M. Imanishi; M. Tomimoto; M. Watanabe; N. Hayashi


Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
273 KB
Volume
23
Category
Article
ISSN
0022-2135

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โœฆ Synopsis


Disodium (+)-(Z)-[[[1-(2-amino-4-~2-14C]thiazolyl)-2-[[(2S,3S)-2-(carbamoyloxymethyl)-4-oxo-l-sulfonato-3-azet izinyl]amino-2-oxoethylidene]aminoloxylacetate ([14C]AMA-1080) was synthesized via [2-(2-chloroacetamido-4-[2-~~C]th~azolyl)-(Z)-2-(4-nitrobenzyloxycarbnylmethoxyimino)]acetic acid from [14C]thiourea. Trisodium (+)-(2)-[[[1-(2-amin0-4-[2-14C]thiazolyl)-2-[[( 1S,2S)-3-carbamoyloxy-1-carboxylato-2-sulfonatoaminopropyl]amino]-2-oxoethylidene]amino]oxy]acetate ([14C]AMA-1294) as t h e principal metabolite of [14C]AMA-1080 was also prepared.


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