𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The synthesis of (5R)- and (5S)-[5-3H]-L-ornithine

✍ Scribed by Ronald J. Parry; Shyhchen Ju; Bill J. Baker

Book ID
102901145
Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
507 KB
Volume
29
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

A practical synthesis of (5R)and (5S)-[5-3H]-L-ornithine is described. The key steps in the synthesis are the reduction of vonnyl-3H]J-hexenal with S-or R-Alpine Borane to (1R)and (1s)-[ 1-3H]J-hexen-l-ol and the use of the Evans electrophilic azidation of c h i d h i d e enolates to introduce the a-amino group of ornithine. The stereochemistry expected for the Alpine Borane reduction was v d i e d by NMR analysis of the camphanate ester derived from reduction of vomyf-2H]-S-hexenal with R-Alpine Borane.

πŸ“œ SIMILAR VOLUMES

Synthesis of L-[5-11C]ornithine
Synthesis of L-[5-11C]ornithine
✍ Yu-Shin Ding; Gunnar Antoni; Joanna S. Fowler; Alfred P. Wolf; Bengt Langstrom πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 French βš– 474 KB

No-carrier-added L-[5-11C]ornithine was synthesized in 25-40% radiochemical yield in a synthesis time of 50 min (EOB) and a specific ac vity >2.1 Ci/umol by the displacement reaction of potassium ['fC]cyanide with the functionally protected y- bromohomoserine followed by selective reduction of the [

Synthesis of (2S, 5R) - [5-2H] Proline
Synthesis of (2S, 5R) - [5-2H] Proline
✍ Paola Gramatica; Paolo Manitto; Ada Manzocchi; Enzo Santaniello πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 French βš– 318 KB

## Abstract The title compound was obtained by preferential crystallisation of (2RS,5R)‐[5‐^2^H]proline. The labelled racemic amino acid was synthesized in five steps from (5R)‐[5‐^2^H]‐2‐pyrrolidone, which was prepared by cyclisation of (4R)‐[4‐^2^H] GABA. The stereospecific label was introduced i