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Synthesis of (2S, 5R) - [5-2H] Proline

✍ Scribed by Paola Gramatica; Paolo Manitto; Ada Manzocchi; Enzo Santaniello

Book ID: 102374629
Publisher: John Wiley and Sons
Year: 1981
Tongue: French
Weight: 318 KB
Volume: 18
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580180705

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The title compound was obtained by preferential crystallisation of (2RS,5R)‐[5‐^2^H]proline. The labelled racemic amino acid was synthesized in five steps from (5R)‐[5‐^2^H]‐2‐pyrrolidone, which was prepared by cyclisation of (4R)‐[4‐^2^H] GABA. The stereospecific label was introduced into GABA enzymatically decarboxylating in ^2^H~2~O (2S)‐glutamic acid, in the presence of glutamate decarboxy lase from E. coli.

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