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Synthesis of [5′-2H1]-nucleosides with defined (5′S)(5′R)-ratios

✍ Scribed by Yu Oogo; Akira (Mei) Ono; Akira Ono; Masatsune Kainosho


Book ID
104259109
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
242 KB
Volume
39
Category
Article
ISSN
0040-4039

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Synthesis of (2S, 5R) - [5-2H] Proline
✍ Paola Gramatica; Paolo Manitto; Ada Manzocchi; Enzo Santaniello 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 318 KB

## Abstract The title compound was obtained by preferential crystallisation of (2RS,5R)‐[5‐^2^H]proline. The labelled racemic amino acid was synthesized in five steps from (5R)‐[5‐^2^H]‐2‐pyrrolidone, which was prepared by cyclisation of (4R)‐[4‐^2^H] GABA. The stereospecific label was introduced i