Synthesis of (2S, 5R) - [5-2H] Proline
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Paola Gramatica; Paolo Manitto; Ada Manzocchi; Enzo Santaniello
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Article
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1981
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John Wiley and Sons
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French
⚖ 318 KB
## Abstract The title compound was obtained by preferential crystallisation of (2RS,5R)‐[5‐^2^H]proline. The labelled racemic amino acid was synthesized in five steps from (5R)‐[5‐^2^H]‐2‐pyrrolidone, which was prepared by cyclisation of (4R)‐[4‐^2^H] GABA. The stereospecific label was introduced i