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ICI 185,282 ((SZ)-7-[(2RS, 4RS, 5SR)-4-o-Wdroxypheny1-Ztri fluoromethyl--1,3-d|~-'an-5--yl ]-~--hepteno|c acid), a novel thromboxane receptor antagonist, has been radiolabelled with 14C for use in metabolism studies. [14C]-ICI 185,282 (1), specific activity 23.8 mCi/mmol, radiochemical purity 98% wa
Owing to an error at proof stage, the molecular structure in Figure 1 was published incorrectly. The revised version is now printed below.
## Abstract The synthesis of radiolabelled 4βhydroxyβ3β(3βmethylβ3βbutenβ1βynyl) benzaldehyde (eutypine 1), a phytotoxic compound isolated from the culture media of the fungus __Eutypa lata__, responsible for vineyard dieβback, is described. The radioisotope ^14^C was introduced __via__ a Wittig re
14C-Labelled satigrel, or 4-cyano-5-(4'-methoxy tring-U-14CI phenyl)-5-(4"methoxyphenyl)-4-pentenoic acid was synthesized for drug metabolism and pharmacokinetic studies using 4,4'-diniethoxy [ring-U-W ] benzophenone as the starting material. The radiochemical yield was 10.0%. The specific radioacti