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The synthesis of 14C-labeled suicide inactivators of monoamine oxidase

✍ Scribed by Joanna S. Fowler

Publisher: John Wiley and Sons
Year: 1978
Tongue: French
Weight: 140 KB
Volume: 14
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580140317

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✦ Synopsis

Abstract

N‐[3‐(2,4‐dichlorophenoxy)propyl]‐N‐methyl‐2‐propynylamine‐1‐^14^C (^14^C‐clorgyline, 1a) and L‐N, α‐dimethyl‐N‐2‐propynyl‐1‐^14^C‐phenethylamine (^14^C‐L deprenyl, 1b) were synthesized by the Mannich reaction of 2‐methyl‐3‐butyn‐2‐ol, ^14^C‐formaldehyde, and secondary amines 3‐(2,4‐dichlorophenoxy)‐N‐methylpropylamine (2a) or L‐N, α‐dimethylphenethylamine (2b) followed by KOH catalyzed elimination of acetone from the respective Mannich base 3a or 3b.

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