✦ LIBER ✦

The synthesis and resolution of tritiated 4-amino-3-phenylbutanoic acid ([3H]R- and [3H]S-β-phenylgaba)

✍ Scribed by Rujee K. Duke; Robin D. Allan; Colleen A. Drew; Graham A. R. Johnston; Kenneth N. Mewett; Mervyn A. Long; Chit Than

Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 396 KB
Volume: 33
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580330813

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A synthesis of [^3^H]R‐ and [^3^H]S‐4‐amino‐3‐phenylbutanoic acid ([^3^H]R‐ and [^3^H]S‐β‐phenylGABA) from the unsaturated intermediate by catalytic hydrogenation using tritium gas in the presence of palladium on charcoal is reported. The [^3^H]R‐ and [^3^H]S‐diastereoisomers of pantolactone ester of β‐phenylGABA were separated by HPLC.

📜 SIMILAR VOLUMES

A facile and regiospecific tritiation of

A facile and regiospecific tritiation of sphingosine: Synthesis of (2S,3R,4E)-2-amino-4-octadecene-1,3-diol-1-3H

✍ Tatsushi Toyokuni; Mohammad Nisar; Barbara Dean; Sen-Itiroh Hakomori 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 349 KB

## Abstract An easy technique for introduction of tritium into the 1‐position of sphingosine was developed, employing regiospecific oxidation of the primary hydroxy group followed by reduction with NaB^3^H~4~. An improved preparation of __N__,__N__‐dimethylsphingosine and its quaternization are als

Chirospecific Synthesis of the (2S,3R)-

Chirospecific Synthesis of the (2S,3R)- and (2S,3S)-3-Amino-2-hydroxy-4-phenylbutanoic Acids from Sugar: Application to (-)-Bestatin (I).

✍ Jin Hwan Lee; Byong Won Lee; Ki Chang Jang; Ill-Yun Jeong; Min Suk Yang; Sang Gy 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 60 KB 👁 1 views

Synthesis of racemic, S(+)- and R(-)-N-[

Synthesis of racemic, S(+)- and R(-)-N-[methyl-3H]3,4-methylenedioxymethamphetamine

✍ Kenji Hashimoto; Katsumi Hirai; Tsuyoshi Goromaru 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 158 KB 👁 1 views

## Abstract The synthesis of 3,4‐methylenedioxymethamphetamine(MDMA), a serotonergic neurotoxin, labeled with tritium is described. Labeling was accomplished by N‐alkylation of the free base of the corresponding desmethyl compound using [^3^H]methyl iodide. The compound was purified by preparative

ChemInform Abstract: Synthesis of (2S,3R

ChemInform Abstract: Synthesis of (2S,3R)-3-Amino-2-hydroxydecanoic Acid (VII) and (3R,4R)- 3-Amino-4-hydroxyazepane (XII) from D-Isoascorbic Acid.

✍ A. TUCH; M. SANIERE; Y. LE MERRER; J.-C. DEPEZAY 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Short Synthesis of (R)- and (S)-4-Amino-

Short Synthesis of (R)- and (S)-4-Amino-3-hydroxybutyric Acid (GABOB).

✍ Marcello Tiecco; Lorenzo Testaferri; Andrea Temperini; Raffaella Terlizzi; Luana 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 21 KB 👁 2 views

The synthesis of (2R)- and (2S)-[2-3H]-p

The synthesis of (2R)- and (2S)-[2-3H]-propionic acid

✍ Ronald J. Parry; Rajesh Turakhia 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 365 KB 👁 1 views

## Abstract A practical synthesis of (2R)‐ and (2S)‐[2‐^3^H]‐propionic acid is described. The key steps in the synthesis are the reduction of [__formyl__‐^3^H]‐3‐methoxy‐4‐mesyloxybenzaldehyde with R‐ or S‐Alpine Borane to (7S)‐ and (7R)‐[7‐^3^H]‐3‐methoxy‐4‐mesyloxybenzyl alcohol and the use of th