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Synthesis of racemic, S(+)- and R(-)-N-[methyl-3H]3,4-methylenedioxymethamphetamine

✍ Scribed by Kenji Hashimoto; Katsumi Hirai; Tsuyoshi Goromaru

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
158 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of 3,4‐methylenedioxymethamphetamine(MDMA), a serotonergic neurotoxin, labeled with tritium is described. Labeling was accomplished by N‐alkylation of the free base of the corresponding desmethyl compound using [^3^H]methyl iodide. The compound was purified by preparative HPLC. The radiochemical yield was about 60% based on [^3^H]methyl iodide. The radiochemical purity was more than 95% from HPLC and TLC. Furthermore, S(+)‐ and R(‐)‐[^3^H]MDMA were completely separated by analytical HPLC with chiral column.

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