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The synthesis of (2R)- and (2S)-[2-3H]-propionic acid

✍ Scribed by Ronald J. Parry; Rajesh Turakhia

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
365 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A practical synthesis of (2R)‐ and (2S)‐[2‐^3^H]‐propionic acid is described. The key steps in the synthesis are the reduction of [formyl‐^3^H]‐3‐methoxy‐4‐mesyloxybenzaldehyde with R‐ or S‐Alpine Borane to (7S)‐ and (7R)‐[7‐^3^H]‐3‐methoxy‐4‐mesyloxybenzyl alcohol and the use of the vanillyl moiety as a masked carboxyl group.

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