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A facile and regiospecific tritiation of sphingosine: Synthesis of (2S,3R,4E)-2-amino-4-octadecene-1,3-diol-1-3H

✍ Scribed by Tatsushi Toyokuni; Mohammad Nisar; Barbara Dean; Sen-Itiroh Hakomori

Publisher: John Wiley and Sons
Year: 1991
Tongue: French
Weight: 349 KB
Volume: 29
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580290508

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✦ Synopsis

Abstract

An easy technique for introduction of tritium into the 1‐position of sphingosine was developed, employing regiospecific oxidation of the primary hydroxy group followed by reduction with NaB^3^H~4~. An improved preparation of N,N‐dimethylsphingosine and its quaternization are also described.

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