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The structure of salinomycin, a new member of the polyether antibiotics

✍ Scribed by Haruyasu Kinashi; Noboru Ōtake; Hiroshi Yonehara; Shoichi Sato; Yoshihiko Saito

Publisher
Elsevier Science
Year
1973
Tongue
French
Weight
168 KB
Volume
14
Category
Article
ISSN
0040-4039

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✦ Synopsis

Salinomycin'

is a new antibiotic elaborated by the strain of Streptomyces aZbus and has an antimicrobial activity against Gram-positive bacteria, mycobacteria and fungi. Furthermore, salinomycin is effective in the treatment of coccidial infections in poultry.

In light of its biological activity coupled with the physicochemical properties and spectral data, the antibiotic is assumed to belong to a new member of the polyether antibiotics.

In this communication, we wish to report the structural elucidation of salinomycin p-iodophenacyl ester by X-ray analysis as depicted formula (I).

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