✦ LIBER ✦
A highly stereocontrolled total synthesis of the polyether antibiotic salinomycin. Crucial role of the 40-metoxybenzyl; (mpm) protecting group for hydroxy functions
✍ Scribed by Kiyoshi Horita; Yuji Oikawa; Satoshi Nagato; Osamu Yonemitsu
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 310 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Salinomycin was synthesized from D-glucose, D-mannitol, and ethyl L-lactate via coupling of Cl-C9, ClO-C17, and C18-C30 segments. Benzyl-type protecting groups as well as regioand stereoselective reactions played a crucial role.