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The structure of a new nucleoside antibiotic, capuramycin

✍ Scribed by Haruo Seto; Noboru Otake; Shingo Sato; Hiroshi Yamaguchi; Kinji Takada; Masayoshi Itoh; Helen S.M. Lu; Jon Clardy

Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
260 KB
Volume
29
Category
Article
ISSN
0040-4039

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✦ Synopsis

The structure of capuramycin has been determined to be an uracll nucleoside with a caprolactam substltuent as shown in Fig. 5 by NMR spectral analysis, chemical degradation and X-ray analysis.

During the course of our screening program for new antibiotics, it was found that Streptomyces nrlseus 446-S3 produced a new nucleoslde antibiotic which we have named capuramycln (I).

This antibiotic was isolated from the fermentation broth by adsorption on HP-20 followed by silica gel (CHC13:MeOH =

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